A Multi-Omics Human Liver Organoid Screening Platform for DILI Risk Prediction
Drug-induced liver injury (DILI) is a prominent failure mode in drug development resulting in clinical trial failures and post-approval [...]
June 2022
In Vitro Evaluation and Mitigation of Niclosamide’s Liabilities as a COVID-19 Treatment
Niclosamide, an FDA-approved oral anthelmintic drug, has broad biological activity including anticancer, antibacterial, and antiviral properties. Niclosamide has also [...]
March 2022
Evaluating the in vitro efficacy of bovine lactoferrin products against SARS-CoV-2 variants of concern
In this manuscript, we evaluated the efficacy of Lactoferrin against several SARS-CoV-2 variants of concern. Lactoferrin showed strong efficacy [...]
April 2021
The effect of ultraviolet C radiation against different N95 respirators inoculated with SARS-CoV-2
The effect of ultraviolet C radiation against different N95 respirators inoculated with SARS-CoV-2 Objectives: There are currently no studies that [...]
SARS-CoV-2 receptor networks in diabetic and COVID-19-associated kidney disease
SARS-CoV-2 receptor networks in diabetic and COVID-19–associated kidney disease: COVID-19 morbidity and mortality are increased via unknown mechanisms in [...]
February 2021
Nuisance compounds in cellular assays
Compounds that exhibit assay interference or undesirable mechanisms of bioactivity (‘‘nuisance compounds’’) are routinely encountered in cellular assays, including [...]
Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2
Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2 This study is published in PNAS and details the role the Ace2 [...]
SARS-CoV-2 Drug Repurposing Study
Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 In this study, we used high content [...]
December 2019
The focal adhesion scaffold protein Hic-5 regulates vimentin organization in fibroblasts
In a collaborative effort, the Sexton lab helped to quantitate cellular morphologies to establish that Hic-5 regulates vimentin organization [...]
July 2019
#HCABootcamp in Utrecht
Group photo of our High Content bootcamp in Utrecht, Netherlands.