Nuisance compounds in cellular assays
Compounds that exhibit assay interference or undesirable mechanisms of bioactivity (‘‘nuisance compounds’’) are routinely encountered in cellular assays, including [...]
February 2021
Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2
Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2 This study is published in PNAS and details the role the Ace2 [...]
SARS-CoV-2 Drug Repurposing Study
Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 In this study, we used high content [...]
December 2019
The focal adhesion scaffold protein Hic-5 regulates vimentin organization in fibroblasts
In a collaborative effort, the Sexton lab helped to quantitate cellular morphologies to establish that Hic-5 regulates vimentin organization [...]
July 2019
#HCABootcamp in Utrecht
Group photo of our High Content bootcamp in Utrecht, Netherlands.
June 2018
High Content Screening – Human Muscle Stem Cells
High-Content Screening of Human Primary Muscle Satellite Cells for New Therapies for Muscular Atrophy/Dystrophy Results are encouraging [...]
Insulin FP Biosensor
Development of a Cell-Based Fluorescence Polarization Biosensor Using Preproinsulin to Identify Compounds That Alter Insulin Granule Dynamics [...]
Niclosamide and Analogs Improve Fatty Liver Disease
N-substituted Phenylbenzamides of the Niclosamide chemotype attenuate obesity related changes in high fat diet fed mice Results [...]
Non Alcoholic Fatty Liver Disease
NAFLD, an epidemic and a health disparity In association with the blanket term “metabolic syndrome” (which can be [...]